Coenzyme Q10 Supplementation for Primary Prevention of Cardiovascular Disease.
Cardiovascular disease (CVD) results from complications from the heart and blood vessels and is a global health burden. However, it is believed that the risk of developing CVD can be reduced by altering a number of modifiable risk factors, such as diet. Nutritional supplements have received a lot of attention as a means of preventing cardiovascular disease. One such supplement is coenzyme Q10 (CoQ10), which is an antioxidant.
Deficiency [deficiency] of CoQ10 has been associated with cardiovascular disease. This review assessed the effectiveness of coenzyme Q10 supplementation in preventing cardiovascular disease. We included trials in which KoQ10 was administered as a single supplement to healthy adults or adults at high risk of cardiovascular disease (but not diagnosed with cardiovascular disease) and measured / assessed cardiovascular events or major CVD risk factors such as blood [arterial ] pressure and lipid levels. We found six completed randomized controlled trials with a total of 218 randomized participants
All of these trials included participants at high risk for cardiovascular disease. Two trials examined the use of CoQ10 supplements only and four trials examined the use of CoQ10 supplements in patients receiving statin therapy. These trials were small and short-term, none assessed / measured cardiovascular events or adverse events, and we classified two of the six trials as high risk of bias. Very few small trials contributed to this analysis and no conclusions can be drawn at this time. We also identified five ongoing trials and their results will in turn be added to the evidence base.
Longer trials needed to determine the effect of coenzyme Q10 on cardiovascular disease.